If grade 3 or 4 toxicity occurs, withhold therapy until acute toxicity and clinical signs resolve and anticoagulant therapy is stable or completed. Resulting reconstituted solution should be clear and colorless and free of visible particles or protein aggregates. Gently direct the NS down the wall of the vial (do not inject forcefully into or onto the powder). Females of reproductive potential should use effective contraception during therapy and for 3 months after the last dose of asparaginase (Based on data from animal reproduction studies, in utero exposure to asparaginase (• Pancreatitis like severe abdominal pain, severe back pain, severe nausea, or vomiting• High blood sugar like confusion, fatigue, increased thirst, increased hunger, passing a lot of urine, flushing, fast breathing, or breath that smells like fruit• Severe cerebrovascular disease like change in strength on one side is greater than the other, trouble speaking or thinking, change in balance, or vision changes• Blood clots like numbness or weakness on one side of the body; pain, redness, tenderness, warmth, or swelling in the arms or legs; change in color of an arm or leg; chest pain; shortness of breath; tachycardia; or coughing up blood• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Kloos, Raphaële R.L. Hence, for the patients with a hypersensitivity reaction in whom, according to scenario 2, the asparaginase therapy would have been permanently stopped, we have subtracted the weighted mean difference in EFS reported in the literature, from the EFS of ALL‐10.Both the QALYs and the number of LYS were discounted by 1.5% per year to account for the value of time, according to Dutch guidelines.Data were analyzed with SPSS Statistics version 21.0 (IBM Corporation, Armonk, New York, USA) and MS Excel 2013 (Microsoft Corporation, Redmond, WA, USA). The study was approved by the Institutional Review Board. If grade 3 toxicity occurs, discontinue therapy; if CNS signs/symptoms are fully resolved and further asparaginase doses are required, may resume therapy at a lower dose and/or longer intervals between doses. Monitor glucose levels (baseline and periodic) during treatment. Asparaginases can be used for different industrial and pharmaceutical purposes. Any queries (other than missing content) should be directed to the corresponding author for the article.Please check your email for instructions on resetting your password.
In addition, in these patients, the day care admissions for To assess the health‐related quality of life (HRQoL), the Health Utilities Index (HUI) survey version 3.0Beside the validated HUI questions, several extra questions about the impact of an allergic reaction and change in dosing schedule were added to the questionnaire. Results: In base case analyses, first-line pegaspargase (followed by Erwinia asparaginase in cases of hypersensitivity) dominated first-line native asparaginase followed by Erwinia asparaginase; i.e.
Discontinue therapy for grade 4 toxicity.Hemorrhage: Discontinue therapy; do not withhold therapy for abnormal laboratory findings without a clinical correlate. A decision tree model was developed in order to compare the costs and effects of scenario 1, which included a switch to To account for uncertainty in the calculated costs per LYS, a one‐way sensitivity analysis was performed. In this figure, the costs and life years saved are calculated for each scenario. However, this would be unethical to study so the difference in EFS used is the best available evidence.