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Furthermore, a greater improvement in HDL‐cholesterol responses to exercise seems to occur in men compared with women and in more severely obese individuals.
It appears that the heart needs an optimal balance of glucose and fatty acids to maintain normal biochemistry and physiology, and chronically altering this balance leads to cardiac dysfunction.Arguably the most productive lines of research related to the tissue-specific effects of LPL on lipid fuel partitioning, body weight regulation, and insulin action have come from genetic modifications of the LPL gene in skeletal muscle.Skeletal muscle is a major site for LPL synthesis, and skeletal muscle is also the major tissue responsible for whole body insulin-stimulated glucose uptake/disposal. 1122 August 2019 | Journal of Biological Chemistry, Vol.
12, No. 54, No. 931 March 2016 | Journal of Lipid Research, Vol. (There is evidence to indicate that improvements in HDL‐cholesterol levels occur only when threshold exercise intensities or duration are reached (From the preceding sections, it is clear that excess weight and adiposity are linked to low HDL‐cholesterol levels in obese individuals. 1Circulation: Cardiovascular Genetics, Vol. This was confirmed by a later study in which the level of intra‐abdominal fat, as measured by magnetic resonance imaging, strongly correlated with the clearance rate of HDL apo A‐I (The enhancement in HDL catabolism in obese states may be attributed to enhanced hepatic lipase and CETP activity levels in obesity. 3Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.
1Evidence-Based Complementary and Alternative Medicine, Vol. 1821, No. OBESITY AND LIPOPROTEIN LIPASE Adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipocytokines such as adipsin [32], leptin [33], plasminogen activator inhibitor-1 …
55, No.
74, No. Obese subjects have elevated adipose tissue lipoprotein lipase activity per fat cell when compared with lean control subjects. 2015Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 4310 July 2019 | The Journal of Nutrition, Vol. 26, No.
125 January 2018 | The International Journal of Artificial Organs, Vol. 7, No. 95, No. Therefore, it is imperative to determine the mechanisms responsible for reduced HDL in obese states and, conversely, to examine therapies aimed at increasing HDL levels in these individuals.
However, in a study with 25 human subjects consuming either a high-carbohydrate diet [50% carbohydrate (CHO), 30% fat] for 2 wk or a high-fat diet (50% fat, 30% CHO) for 2 wk, followed by the alternative diet for 2 wk, the high-carbohydrate exposure increases the LPL response to feeding in both adipose tissue and skeletal muscle (The mechanism for LPL regulation in the heart appears to be more complex. 102, No. 27, No. 486, No.
Ostlund et al. 416 March 2017 | Nature Reviews Cardiology, Vol. In adipose tissue, another locus controlling LPL activity appears to affect the translation and/or posttranslational expression of the enzyme (There are several examples of translational regulation of LPL activity. 331 January 2012 | European Journal of Clinical Investigation, Vol.
49 February 2013 | Journal of Veterinary Internal Medicine, Vol. , Determinants of cholesterol efflux capacity in humans, Characterization and prevalence of metabolic syndrome among overweight and obese young Palestinian students at An-Najah National University, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Arteriosclerosis, Thrombosis, and Vascular Biology, Emerging Roles for Adipose Tissue in Cardiovascular Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, Truncal Adiposity Influences High-Density Lipoprotein Cholesterol Levels and Cardiovascular Events in Hemodialysis Patients, Effects of weight change on HDL-cholesterol and its subfractions in over 28,000 men and women, Reference intervals for 33 biochemical analytes in healthy Indian population: C-RIDL IFCC initiative, Clinical Chemistry and Laboratory Medicine (CCLM), Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study, Metabolic syndrome among overweight and obese adults in Palestinian refugee camps, The relationship between hypovitaminosis D and metabolic syndrome: a cross sectional study among employees of a private university in Lebanon, Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3–8 Years Earlier, Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications, Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria, Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss, Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats, The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism, Relationships between different types of physical activity and metabolic syndrome among Taiwanese workers, Autophagy: An overview and its roles in cancer and obesity, Effects of Erythrocyte Membrane Polyunsaturated Fatty Acids in Overweight, Obese, and Morbidly Obese Korean Women, Obesity, adipokines, and C-peptide are associated with distinct plasma phospholipid profiles in adult males, an untargeted lipidomic approach, Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats, The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity‐related traits and mediates by interacting with Apo‐A1, Effects of Myricetin‐Containing Ethanol Solution on High‐Fat Diet Induced Obese Rats, Using molecular functional networks to manifest connections between obesity and obesity-related diseases, Rs214101 Variation of NUCB2/Nesfatin-1 Gene: Effects on Metabolic Parameters Independent of Type 2 Diabetes or Obesity in Coronary Artery Disease, A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan, Gum arabic suppressed diet-induced obesity by alteration the expression of mRNA levels of genes involved in lipid metabolism in mouse liver, Morphology-Induced Defects Enhance Lipid Transfer Rates, A high-density lipoprotein-mediated drug delivery system, Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK), High-density lipoprotein cholesterol (HDL-C) in cardiovascular disease: effect of exercise training, Anthocyanins in obesity-associated thrombogenesis: a review of the potential mechanism of action, Effects of 12 Weeks of Commuting Via Public Transportation on Cardiovascular Function and Obesity Indices in Middle Aged Men, Serum amyloid A impairs the antiinflammatory properties of HDL, Gum arabic decreased visceral adipose tissue associated with downregulation of 11β-hydroxysteroid dehydrogenase type I in liver and muscle of mice, Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats, Biochemical and Biophysical Research Communications, HDL subclasses are heterogeneous in their associations with body fat, as measured by dual-energy X-ray absorptiometry: The Kitakata Kids Health Study, A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome, Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction), Exploring the impact of bariatric surgery on high density lipoprotein, Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates, Prevalence of obesity in panama: some risk factors and associated diseases, Association of cardiometabolic risk profile with prehypertension accompany hyperhomocysteinaemia, Exercise-Induced Biological and Psychological Changes in Overweight and Obese Individuals: A Review of Recent Evidence, Mendelian Disorders of High-Density Lipoprotein Metabolism, Lifestyle and high density lipoprotein cholesterol in postmenopause, Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association, Impact of Isolated Low HDL Cholesterolemia on the Risk of Coronary Artery Disease: A 4-Year Community-Based Prospective Study, Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia, American Journal of Physiology-Endocrinology and Metabolism, L’huile des co-produits de poisson corrige la dyslipidémie, améliore le transport inverse du cholestérol et stimule l’activité de la paraoxonase-1 chez le rat obèse, Age, abdominal obesity, and baseline high-sensitivity C-reactive protein are associated with low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B responses to ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome, Obesity and High-density lipoprotein Cholesterol (HDL-C) : The Recent Related Research Trend Including New Generation Drugs for HDL-C, Changes in weight loss and lipid profiles after a dietary purification program: a prospective case series, Lipid digestion, absorption and uptake in Solea senegalensis, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches, The Effect of Exercise on the Cardiovascular Risk Factors Constituting the Metabolic Syndrome, Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats, Activité physique dans la prise en charge de l’obésité : effets bénéfiques et modalités pratiquesPhysical activity in the treatment of obesity: benefits and modalities, Regulation of adipocyte autophagy — The potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I, Lipid profile changes after pronounced weight loss induced by bariatric surgery, A Gender-Specific Nutritional Approach to Women’s Healthcare, Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes, Apolipoprotein A‐I possesses an anti‐obesity effect associated with increase of energy expenditure and up‐regulation of UCP1 in brown fat, Effects of tea combined with high-protein meal replacement shakes on anthropometric measurements, lipid profiles, cellular biochemistry, neurochemistry, and microbial metabolism: a prospective observational study, Effects of Diet on High-Density Lipoprotein Cholesterol, The Effects of Very-Low-Calorie Diets on HDL: A Review, New insights into the mechanism of low high-density lipoprotein cholesterol in obesity, Impact of a combined diet and progressive exercise intervention for overweight and obese children: the B.E.
8, No.
52, No. 2Trends in Endocrinology & Metabolism, Vol. 130 June 2020 | Current Opinion in Lipidology, Vol. We show that a novel potent inhibitor of HSL does not inhibit other lipases.
Furthermore, a greater improvement in HDL‐cholesterol responses to exercise seems to occur in men compared with women and in more severely obese individuals.
It appears that the heart needs an optimal balance of glucose and fatty acids to maintain normal biochemistry and physiology, and chronically altering this balance leads to cardiac dysfunction.Arguably the most productive lines of research related to the tissue-specific effects of LPL on lipid fuel partitioning, body weight regulation, and insulin action have come from genetic modifications of the LPL gene in skeletal muscle.Skeletal muscle is a major site for LPL synthesis, and skeletal muscle is also the major tissue responsible for whole body insulin-stimulated glucose uptake/disposal. 1122 August 2019 | Journal of Biological Chemistry, Vol.
12, No. 54, No. 931 March 2016 | Journal of Lipid Research, Vol. (There is evidence to indicate that improvements in HDL‐cholesterol levels occur only when threshold exercise intensities or duration are reached (From the preceding sections, it is clear that excess weight and adiposity are linked to low HDL‐cholesterol levels in obese individuals. 1Circulation: Cardiovascular Genetics, Vol. This was confirmed by a later study in which the level of intra‐abdominal fat, as measured by magnetic resonance imaging, strongly correlated with the clearance rate of HDL apo A‐I (The enhancement in HDL catabolism in obese states may be attributed to enhanced hepatic lipase and CETP activity levels in obesity. 3Arteriosclerosis, Thrombosis, and Vascular Biology, Vol.
1Evidence-Based Complementary and Alternative Medicine, Vol. 1821, No. OBESITY AND LIPOPROTEIN LIPASE Adipose tissue participates in the regulation of energy homeostasis as an important endocrine organ that secretes a number of biologically active adipocytokines such as adipsin [32], leptin [33], plasminogen activator inhibitor-1 …
55, No.
74, No. Obese subjects have elevated adipose tissue lipoprotein lipase activity per fat cell when compared with lean control subjects. 2015Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 4310 July 2019 | The Journal of Nutrition, Vol. 26, No.
125 January 2018 | The International Journal of Artificial Organs, Vol. 7, No. 95, No. Therefore, it is imperative to determine the mechanisms responsible for reduced HDL in obese states and, conversely, to examine therapies aimed at increasing HDL levels in these individuals.
However, in a study with 25 human subjects consuming either a high-carbohydrate diet [50% carbohydrate (CHO), 30% fat] for 2 wk or a high-fat diet (50% fat, 30% CHO) for 2 wk, followed by the alternative diet for 2 wk, the high-carbohydrate exposure increases the LPL response to feeding in both adipose tissue and skeletal muscle (The mechanism for LPL regulation in the heart appears to be more complex. 102, No. 27, No. 486, No.
Ostlund et al. 416 March 2017 | Nature Reviews Cardiology, Vol. In adipose tissue, another locus controlling LPL activity appears to affect the translation and/or posttranslational expression of the enzyme (There are several examples of translational regulation of LPL activity. 331 January 2012 | European Journal of Clinical Investigation, Vol.
49 February 2013 | Journal of Veterinary Internal Medicine, Vol. , Determinants of cholesterol efflux capacity in humans, Characterization and prevalence of metabolic syndrome among overweight and obese young Palestinian students at An-Najah National University, Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Arteriosclerosis, Thrombosis, and Vascular Biology, Emerging Roles for Adipose Tissue in Cardiovascular Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, Truncal Adiposity Influences High-Density Lipoprotein Cholesterol Levels and Cardiovascular Events in Hemodialysis Patients, Effects of weight change on HDL-cholesterol and its subfractions in over 28,000 men and women, Reference intervals for 33 biochemical analytes in healthy Indian population: C-RIDL IFCC initiative, Clinical Chemistry and Laboratory Medicine (CCLM), Variation in Exhaled Acetone and Other Ketones in Patients Undergoing Bariatric Surgery: a Prospective Cross-sectional Study, Metabolic syndrome among overweight and obese adults in Palestinian refugee camps, The relationship between hypovitaminosis D and metabolic syndrome: a cross sectional study among employees of a private university in Lebanon, Cardiometabolic Health in Relation to Lifestyle and Body Weight Changes 3–8 Years Earlier, Specialized Pro-resolving Lipid Mediators: Modulation of Diabetes-Associated Cardio-, Reno-, and Retino-Vascular Complications, Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria, Subcutaneous adipose tissue gene expression and DNA methylation respond to both short- and long-term weight loss, Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats, The effect of weight loss on HDL subfractions and LCAT activity in two genotypes of APOA-II -265T>C polymorphism, Relationships between different types of physical activity and metabolic syndrome among Taiwanese workers, Autophagy: An overview and its roles in cancer and obesity, Effects of Erythrocyte Membrane Polyunsaturated Fatty Acids in Overweight, Obese, and Morbidly Obese Korean Women, Obesity, adipokines, and C-peptide are associated with distinct plasma phospholipid profiles in adult males, an untargeted lipidomic approach, Antihyperlidemic Effects of Mangosteen (Garcinia mangostana L.) Pericarp Ethanolic Extract In High-Carbohydrate Wistar Rats, The TCN2 variant of rs9606756 [Ile23Val] acts as risk loci for obesity‐related traits and mediates by interacting with Apo‐A1, Effects of Myricetin‐Containing Ethanol Solution on High‐Fat Diet Induced Obese Rats, Using molecular functional networks to manifest connections between obesity and obesity-related diseases, Rs214101 Variation of NUCB2/Nesfatin-1 Gene: Effects on Metabolic Parameters Independent of Type 2 Diabetes or Obesity in Coronary Artery Disease, A pooled analysis of the association of isolated low levels of high-density lipoprotein cholesterol with cardiovascular mortality in Japan, Gum arabic suppressed diet-induced obesity by alteration the expression of mRNA levels of genes involved in lipid metabolism in mouse liver, Morphology-Induced Defects Enhance Lipid Transfer Rates, A high-density lipoprotein-mediated drug delivery system, Ethanol extract of Pinus koraiensis leaves containing lambertianic acid exerts anti-obesity and hypolipidemic effects by activating adenosine monophosphate-activated protein kinase (AMPK), High-density lipoprotein cholesterol (HDL-C) in cardiovascular disease: effect of exercise training, Anthocyanins in obesity-associated thrombogenesis: a review of the potential mechanism of action, Effects of 12 Weeks of Commuting Via Public Transportation on Cardiovascular Function and Obesity Indices in Middle Aged Men, Serum amyloid A impairs the antiinflammatory properties of HDL, Gum arabic decreased visceral adipose tissue associated with downregulation of 11β-hydroxysteroid dehydrogenase type I in liver and muscle of mice, Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats, Biochemical and Biophysical Research Communications, HDL subclasses are heterogeneous in their associations with body fat, as measured by dual-energy X-ray absorptiometry: The Kitakata Kids Health Study, A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome, Impact of low level of high-density lipoprotein-cholesterol sampled in overnight fasting state on the clinical outcomes in patients with acute myocardial infarction (difference between ST-segment and non-ST-segment-elevation myocardial infarction), Exploring the impact of bariatric surgery on high density lipoprotein, Effects of Nanoparticle Morphology and Acyl Chain Length on Spontaneous Lipid Transfer Rates, Prevalence of obesity in panama: some risk factors and associated diseases, Association of cardiometabolic risk profile with prehypertension accompany hyperhomocysteinaemia, Exercise-Induced Biological and Psychological Changes in Overweight and Obese Individuals: A Review of Recent Evidence, Mendelian Disorders of High-Density Lipoprotein Metabolism, Lifestyle and high density lipoprotein cholesterol in postmenopause, Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association, Impact of Isolated Low HDL Cholesterolemia on the Risk of Coronary Artery Disease: A 4-Year Community-Based Prospective Study, Characterization of a novel genetically obese mouse model demonstrating early onset hyperphagia and hyperleptinemia, American Journal of Physiology-Endocrinology and Metabolism, L’huile des co-produits de poisson corrige la dyslipidémie, améliore le transport inverse du cholestérol et stimule l’activité de la paraoxonase-1 chez le rat obèse, Age, abdominal obesity, and baseline high-sensitivity C-reactive protein are associated with low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B responses to ezetimibe/simvastatin and atorvastatin in patients with metabolic syndrome, Obesity and High-density lipoprotein Cholesterol (HDL-C) : The Recent Related Research Trend Including New Generation Drugs for HDL-C, Changes in weight loss and lipid profiles after a dietary purification program: a prospective case series, Lipid digestion, absorption and uptake in Solea senegalensis, Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, Lipoprotein Subfractions in Metabolic Syndrome and Obesity: Clinical Significance and Therapeutic Approaches, The Effect of Exercise on the Cardiovascular Risk Factors Constituting the Metabolic Syndrome, Dietary d‐Psicose Reduced Visceral Fat Mass in High‐Fat Diet‐Induced Obese Rats, Activité physique dans la prise en charge de l’obésité : effets bénéfiques et modalités pratiquesPhysical activity in the treatment of obesity: benefits and modalities, Regulation of adipocyte autophagy — The potential anti-obesity mechanism of high density lipoprotein and ApolipoproteinA-I, Lipid profile changes after pronounced weight loss induced by bariatric surgery, A Gender-Specific Nutritional Approach to Women’s Healthcare, Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes, Apolipoprotein A‐I possesses an anti‐obesity effect associated with increase of energy expenditure and up‐regulation of UCP1 in brown fat, Effects of tea combined with high-protein meal replacement shakes on anthropometric measurements, lipid profiles, cellular biochemistry, neurochemistry, and microbial metabolism: a prospective observational study, Effects of Diet on High-Density Lipoprotein Cholesterol, The Effects of Very-Low-Calorie Diets on HDL: A Review, New insights into the mechanism of low high-density lipoprotein cholesterol in obesity, Impact of a combined diet and progressive exercise intervention for overweight and obese children: the B.E.
8, No.
52, No. 2Trends in Endocrinology & Metabolism, Vol. 130 June 2020 | Current Opinion in Lipidology, Vol. We show that a novel potent inhibitor of HSL does not inhibit other lipases.