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UCSF chimera - a visualization system for exploratory research and analysis.
Refinement statistics are shown in Pilin subunits are connected in the Nm T4P by contacts between the globular domains, between the globular domains and the α1s, and between the α1s themselves. Genome Structure.
The meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cells. Isolated septic pericarditis or septic arthritis can also be a presentation, and an autoimmune- or antibody-mediated polyarthritis can be seen in the recovery phase following invasive meningococcal disease.
initiated the collaboration, cloned the The authors declare no competing financial interests.The cryoEM map is shown in grey with the T4P model shown as a ribbon representation. Images were stored containing seven ‘chunks’, where each chunk represents a set of frames corresponding to a dose of Approximately 100,000 overlapping pilus segments, each 384 px long and shifted by 15 px (The Nm ΔN-PilE structure (residues 29–161) was docked into the pilus reconstruction using the ‘Fit in Map’ tool in ChimeraThe resolution of the final reconstruction was estimated at The Nm ΔN-PilE was deposited in the PDB under accession number Coureuil, M. et al.
The Gram-negative bacterium Neisseria meningitidis is a frequent commensal of the human upper respiratory tract (46).
In the AcrIIC3-inhibited conformation, 2 AcrIIC3 monomers tether 2 Nme1Cas9 RNPs together. A. Reassortment of pilin genes in Potts, W. J. Nme1Cas9 and Nme2Cas9 are compact nucleases for We use cookies to help provide and enhance our service and tailor content and ads.
Egelman, E. H. Ambiguities in helical reconstruction. Neisseria meningitidis causes meningococcal disease with an annual incidence of 1:100,000 persons in Europe and has a case fatality rate of 8% (Trotter & Ramsay, 2007).Meningococcal disease was first described in the late winter and spring in Geneva, Switzerland, in 1805, as “an epidemic outbreak of rapid onset, hemorrhagic eruption, febrile course, and high mortality with gross inflammation of the central nervous system.”From a clinicopathologic perspective, Thomas Willis (1621–1675) was the first to document patients with ‘inflammation of the meninges with a continual fever’, as well as describe a 1661 epidemic of meningitis. The structures allow development of a model in which the sequential hydrolysis of ATP is coupled to motions of ClpX loops that lead to directional substrate translocation and ClpX rotation relative to ClpP. Forest, K. T. et al. We do not retain these email addresses.ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Relation to the inflammatory response. Hospenthal, M. K. et al. A deliberate approach to screening for initial crystallization conditions of biological macromolecules. For example, Recently, we demonstrated that a surprisingly large fraction (about 9%) of meningococcal disease isolates have lipid A with only five acyl chains, due to inactivating mutations in the acyl-transferase gene In this study we wanted to compare the virulence of the The bacteria also contain other components that can be recognized by pattern recognition receptors that contribute to the innate immune response (Disease severity in mice infected with strain H44/76 or the Number of bacteria in blood after infection. Five structures of Neisseria meningitidis Cas9s show distinct reaction states • An Nme1Cas9 structure reveals the catalytically activated HNH domain conformation • The HNH catalytic conformation promotes activation of the RuvC domain • AcrIIC3 inhibits Nme1Cas9 by tethering 2 Nme1Cas9 complexes together The structures reveal the catalytically poised conformation as well as the pre-catalytic and post-cleavage states.
The pathogen has a unique ability among the different etiologic agents of bacterial meningitis to cause major epidemics, case clusters, and hyperendemic as well as endemic disease. & Saunders, J. R. Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Malvankar, N. S. et al. Structure/Function Analysis of Neisseria meningitidis PilW, a Conserved Protein That Plays Multiple Roles in Type IV Pilus Biology Tim H. Szeto , Andréa Dessen , Vladimir Pelicic Infection and Immunity Jul 2011, 79 (8) 3028-3035; DOI: 10.1128/IAI.05313-11
Der einzige Wirt ist der Mensch. Collaborative Computational Project. Colonies appear smooth, moist, and glistening (Rake). Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of We thank Grace (Guixiang) Yang for expression and purification of ΔN-PilE and Pavel Afonine (Lawrence Berkeley National Laboratory) for assistance with Phenix during the construction of the Nm T4P model.
UCSF chimera - a visualization system for exploratory research and analysis.
Refinement statistics are shown in Pilin subunits are connected in the Nm T4P by contacts between the globular domains, between the globular domains and the α1s, and between the α1s themselves. Genome Structure.
The meningococcal minor pilin PilX is responsible for type IV pilus conformational changes associated with signaling to endothelial cells. Isolated septic pericarditis or septic arthritis can also be a presentation, and an autoimmune- or antibody-mediated polyarthritis can be seen in the recovery phase following invasive meningococcal disease.
initiated the collaboration, cloned the The authors declare no competing financial interests.The cryoEM map is shown in grey with the T4P model shown as a ribbon representation. Images were stored containing seven ‘chunks’, where each chunk represents a set of frames corresponding to a dose of Approximately 100,000 overlapping pilus segments, each 384 px long and shifted by 15 px (The Nm ΔN-PilE structure (residues 29–161) was docked into the pilus reconstruction using the ‘Fit in Map’ tool in ChimeraThe resolution of the final reconstruction was estimated at The Nm ΔN-PilE was deposited in the PDB under accession number Coureuil, M. et al.
The Gram-negative bacterium Neisseria meningitidis is a frequent commensal of the human upper respiratory tract (46).
In the AcrIIC3-inhibited conformation, 2 AcrIIC3 monomers tether 2 Nme1Cas9 RNPs together. A. Reassortment of pilin genes in Potts, W. J. Nme1Cas9 and Nme2Cas9 are compact nucleases for We use cookies to help provide and enhance our service and tailor content and ads.
Egelman, E. H. Ambiguities in helical reconstruction. Neisseria meningitidis causes meningococcal disease with an annual incidence of 1:100,000 persons in Europe and has a case fatality rate of 8% (Trotter & Ramsay, 2007).Meningococcal disease was first described in the late winter and spring in Geneva, Switzerland, in 1805, as “an epidemic outbreak of rapid onset, hemorrhagic eruption, febrile course, and high mortality with gross inflammation of the central nervous system.”From a clinicopathologic perspective, Thomas Willis (1621–1675) was the first to document patients with ‘inflammation of the meninges with a continual fever’, as well as describe a 1661 epidemic of meningitis. The structures allow development of a model in which the sequential hydrolysis of ATP is coupled to motions of ClpX loops that lead to directional substrate translocation and ClpX rotation relative to ClpP. Forest, K. T. et al. We do not retain these email addresses.ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.Enter multiple addresses on separate lines or separate them with commas.This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.Relation to the inflammatory response. Hospenthal, M. K. et al. A deliberate approach to screening for initial crystallization conditions of biological macromolecules. For example, Recently, we demonstrated that a surprisingly large fraction (about 9%) of meningococcal disease isolates have lipid A with only five acyl chains, due to inactivating mutations in the acyl-transferase gene In this study we wanted to compare the virulence of the The bacteria also contain other components that can be recognized by pattern recognition receptors that contribute to the innate immune response (Disease severity in mice infected with strain H44/76 or the Number of bacteria in blood after infection. Five structures of Neisseria meningitidis Cas9s show distinct reaction states • An Nme1Cas9 structure reveals the catalytically activated HNH domain conformation • The HNH catalytic conformation promotes activation of the RuvC domain • AcrIIC3 inhibits Nme1Cas9 by tethering 2 Nme1Cas9 complexes together The structures reveal the catalytically poised conformation as well as the pre-catalytic and post-cleavage states.
The pathogen has a unique ability among the different etiologic agents of bacterial meningitis to cause major epidemics, case clusters, and hyperendemic as well as endemic disease. & Saunders, J. R. Identification of epitopes recognized by monoclonal antibodies SM1 and SM2 which react with all pili of Malvankar, N. S. et al. Structure/Function Analysis of Neisseria meningitidis PilW, a Conserved Protein That Plays Multiple Roles in Type IV Pilus Biology Tim H. Szeto , Andréa Dessen , Vladimir Pelicic Infection and Immunity Jul 2011, 79 (8) 3028-3035; DOI: 10.1128/IAI.05313-11
Der einzige Wirt ist der Mensch. Collaborative Computational Project. Colonies appear smooth, moist, and glistening (Rake). Chronic meningococcemia cutaneous lesions involve meningococcal perivascular invasion through the remodeling of endothelial barriers. Structural and evolutionary analyses show unique stabilization strategies in the type IV pili of We thank Grace (Guixiang) Yang for expression and purification of ΔN-PilE and Pavel Afonine (Lawrence Berkeley National Laboratory) for assistance with Phenix during the construction of the Nm T4P model.